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and (3) first weight loss reaching clinically meaningful thresholds of 5%, 10% and 15% from baseline

doi: 10.1016/S0140-6736(18)30726-8 83 EngJKleinmanWASinghLSinghGRaufmanJP

Advise patients to monitor for decreased sweating and increased body temperature during physical activity, especially in hot weather [see Warnings and Precautions (5.11)]

The specific day is flexible, but be sure to rotate injection sites between the abdomen, thigh, or upper arm to avoid irritation

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Why GLP-1 Agonists Outperform Metformin for Weight Loss Metformin was developed as a diabetes medication, not a weight loss drug, so its metabolic effects are indirect and modest